Endocrine Abstracts

The insulin-like growth factor (IGF) signalling pathway plays a fundamental role in regulating growth and development. In extracellular environments, IGFs are present in complexes with high-affinity binding proteins (IGFBPs). Studies using cultured mammalian cell lines and transgenic mice suggest that IGFBPs have the ability to inhibit and/or potentiate IGF actions. Some IGFBPs may even possess intrinsic biological activities that are IGF-independent. The in vivo physio...